Electric field redistribution during tissue electroporation: its potential impact on treatment planning

TitleElectric field redistribution during tissue electroporation: its potential impact on treatment planning
Publication TypeJournal Article
Year of Publication2010
AuthorsIvorra, A, Rubinsky, B, Mir, LM
JournalComptes Rendus Physique
VolumeAccepted (still pending publication)
Abstract
Electroporation is the phenomenon in which cell membrane permeability is increased by exposing the cell to short high electric field pulses. Electroporation is accompanied by an increase of tissue electrical conductivity during the pulses. Such conductivity increase results in a redistribution of the electric field magnitude that can be simulated with simple functions describing the change in tissue conductivity. Experiments on potato tuber reveal that the conductivity increase phenomenon has indeed a significant impact on field distribution, and validate the use of models that take into account such conductivity alteration. For instance, the error in electroporated area estimation can decrease from 30 % to 3 %.