@article {245, title = {Angiographic and histological characterization of PFA-induced coronary spasm: Differential effect of two waveforms}, journal = {Heart Rhythm}, volume = {(In Press, Journal Pre-proof)}, year = {2026}, doi = {10.1016/j.hrthm.2026.03.1904}, url = {https://doi.org/10.1016/j.hrthm.2026.03.1904}, author = {Gerard Amor{\'o}s-Figueras and Q. Castellv{\'\i} and Sergi Casabella-Ramon and Marc Soriano-Amores and {\'A}lvaro Borachok and del Pino, Pablo and Zoraida Moreno-Weidmann and Antoni Ivorra and Jose M. Guerra} } @article {247, title = {Frequency-induced fatigue in electrically stimulated sheep hindlimb muscles}, journal = {Biomedical Physics \& Engineering Express}, volume = {(accepted manuscript online)}, year = {2026}, doi = {10.1088/2057-1976/ae6346}, url = {https://iopscience.iop.org/article/10.1088/2057-1976/ae6346}, author = {Mateu-Yus, Berta and Ana Garcia-Maestre and Aracelys Garc{\'\i}a-Moreno and Antoni Ivorra} } @article {240, title = {The Biomedical Engineer{\textquoteright}s Pledge: Overview and Context}, journal = {Medical \& Biological Engineering \& Computing}, volume = {(Published online)}, year = {2025}, doi = {10.1007/s11517-025-03443-6}, url = {https://doi.org/10.1007/s11517-025-03443-6}, author = {Antoni Ivorra and Txetxu Aus{\'\i}n and Laura Becerra-Fajardo and del Ama, Antonio J. and Jesus Minguillon and Aracelys Garc{\'\i}a-Moreno and Jordi Aguil{\'o} and Filipe O. Barroso and Bijnens, Bart and Oscar Camara and Sara Capdevila and Castellanos-Fernandez, Roger and Rafael Davalos and Jean-Louis Divoux and Ahmed Eladly and Dario Farina and Garc{\'\i}a-Hombravella, Carla and Gonz{\'a}lez-L{\'o}pez, Raquel and C{\'e}sar Gonz{\'a}lez and Jordi Gr{\'\i}fols and Felipe Maglietti and Shahid Malik and Elad Maor and Guillermo Marshall and Mateu-Yus, Berta and Lluis M. Mir and Moreno, Juan C. and Xavier Navarro and N{\'u}ria Noguera and Andr{\'e}s Ozaita and Gemma Piella and Pons, Jos{\'e} Luis and Rita Quesada and Pilar Rivera-Gil and Boris Rubinsky and Ruiz-Garcia, Aurelio and Ruiz-Vargas, Albert and S{\'a}nchez-S{\'a}nchez, Maria and Andreas Schneider and Ting Shu and Villa-Sanz, Rosa and Bing Zhang and Gema Revuelta} } @article {241, title = {Invasive and Non-Invasive Remote Patient Monitoring Devices for Heart Failure: A Comparative Review of Technical Maturity and Clinical Readiness}, journal = {Sensors}, volume = {25}, year = {2025}, chapter = {6453}, doi = {10.3390/s25206453}, url = {https://www.mdpi.com/1424-8220/25/20/6453}, author = {Ivan Luque and Mar Gadea and Anna Comas and Laura Becerra-Fajardo and Javier Col{\'a}s and Antoni Ivorra} } @article {243, title = {Local modifications in tissular conditions before PFA increases acute lesion size}, journal = {Heart Rhythm O2}, volume = {(In press)}, year = {2025}, doi = {10.1016/j.hroo.2025.11.021 }, url = {https://www.heartrhythmopen.com/article/S2666-5018(25)00567-7/fulltext}, author = {Gerard Amor{\'o}s-Figueras and Sergi Casabella-Ramon and Zoraida Moreno-Weidmann and Q. Castellv{\'\i} and Antoni Ivorra and Tomas Garcia-Sanchez and Jose M. Guerra} } @article {233, title = {Is a single lethal electric field threshold sufficient to characterize the lesion size in computational modeling of cardiac pulsed field ablation?}, journal = {Heart Rhythm O2}, volume = {6}, year = {2025}, pages = {671-677}, chapter = {671}, doi = {10.1016/j.hroo.2025.02.014}, url = {https://doi.org/10.1016/j.hroo.2025.02.014}, author = {Argyrios Petras and Gerard Amor{\'o}s-Figueras and Zoraida Moreno-Weidmann and Tomas Garcia-Sanchez and David Vilad{\'e}s Medel and Antoni Ivorra and Jose M. Guerra and Luca Gerardo-Giorda} } @article {231, title = {Changes in local endocardial electrograms immediately after PFA show dose-dependent variations}, journal = {EP Europace}, volume = {26}, year = {2024}, pages = {euae102.755}, chapter = {euae102.755}, doi = {10.1093/europace/euae102.755}, url = {https://academic.oup.com/europace/article/26/Supplement_1/euae102.755/7681509}, author = {Gerard Amor{\'o}s-Figueras and Zoraida Moreno-Weidmann and Sergi Casabella-Ramon and Antoni Ivorra and Jose M. Guerra and Tomas Garcia-Sanchez} } @article {228, title = {Effects of Contact Force on Lesion Size During Pulsed Field Catheter Ablation: Histochemical Characterization of Ventricular Lesion Boundaries}, journal = {Circulation: Arrhythmia and Electrophysiology}, volume = {17}, year = {2024}, pages = {e012026}, chapter = {e012026}, doi = {10.1161/CIRCEP.123.012026}, url = {https://doi.org/10.1161/CIRCEP.123.012026}, author = {Hiroshi Nakagawa and Q. Castellv{\'\i} and Robert Neal and Steven Girouard and Jacob Laughner and Atsushi Ikeda and Masafumi Sugawara and Yoshimori An and Hussein, Ayman A. and Shady Nakhla and Tyler Taigen and Jakub Srounbek and Mohamed Kanj and Pasquale Santangeli and Walid I. Saliba and Antoni Ivorra and Oussama M. Wazni} } @article {227, title = {First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction}, journal = {Journal of NeuroEngineering and Rehabilitation}, volume = {21}, year = {2024}, pages = {4}, chapter = {4}, doi = {10.1186/s12984-023-01295-5}, url = {https://doi.org/10.1186/s12984-023-01295-5}, author = {Laura Becerra-Fajardo and Jesus Minguillon and Krob, Marc O. and Camila Rogrigues and Miguel Gonz{\'a}lez-S{\'a}nchez and {\'A}lvaro Meg{\'\i}a-Garc{\'\i}a and Redondo Gal{\'a}n, Carolina and Guiti{\'e}rrez Henares, Francisco and Albert Comerma and del Ama, Antonio J. and {\'A}ngel Gil-Agudo and Francisco Grandas and Andreas Schneider and Filipe O. Barroso and Antoni Ivorra} } @article {226, title = {Dynamics of High-Density Unipolar Epicardial Electrograms During PFA}, journal = {Circulation: Arrhythmia and Electrophysiology}, year = {2023}, pages = {e011914}, chapter = {e011914}, doi = {10.1161/CIRCEP.123.011914}, url = {https://www.ahajournals.org/doi/10.1161/CIRCEP.123.011914}, author = {Gerard Amor{\'o}s-Figueras and Sergi Casabella-Ramon and Zoraida Moreno-Weidmann and Antoni Ivorra and Jose M. Guerra and Tomas Garcia-Sanchez} } @article {215, title = {Powering Electronic Implants by High Frequency Volume Conduction: In Human Validation}, journal = {IEEE Transactions on Biomedical Engineering}, volume = {70}, year = {2023}, month = {08/2022}, pages = {659-670}, chapter = {659}, doi = {10.1109/TBME.2022.3200409}, url = {https://ieeexplore.ieee.org/document/9864046}, author = {Jesus Minguillon and Marc Tudela-Pi and Laura Becerra-Fajardo and Enric Perera-Bel and del Ama, Antonio J. and {\'A}ngel Gil-Agudo and {\'A}lvaro Meg{\'\i}a-Garc{\'\i}a and Aracelys Garc{\'\i}a-Moreno and Antoni Ivorra} } @article {213, title = {Auricular transcutaneous vagus nerve stimulation acutely modulates brain connectivity in mice}, journal = {Frontiers in Cellular Neuroscience}, volume = {16}, year = {2022}, pages = {856855}, chapter = {856855}, doi = {10.3389/fncel.2022.856855}, url = {https://www.frontiersin.org/articles/10.3389/fncel.2022.856855/abstract}, author = {Cecilia Brambilla-Pisoni and Emma Mu{\~n}oz-Moreno and Ianire Gallego-Amaro and Rafael Maldonado and Antoni Ivorra and Guadalupe Soria and Andr{\'e}s Ozaita} } @article {217, title = {A computational comparison of Radiofrequency and Pulsed Field Ablation in terms of lesion morphology in the cardiac chamber}, journal = {Scientific Reports}, volume = {12}, year = {2022}, chapter = {16144}, doi = {10.1038/s41598-022-20212-9}, url = {https://doi.org/10.1038/s41598-022-20212-9}, author = {Mario G{\'o}mez-Barea and Tomas Garcia-Sanchez and Antoni Ivorra} } @article {209, title = {Modeling methods for treatment planning in overlapping electroporation treatments}, journal = {IEEE Transactions on Biomedical Engineering}, volume = {69}, year = {2022}, month = {09/2021}, pages = {1318 - 1327}, chapter = {1318}, doi = {10.1109/TBME.2021.3115029}, url = {https://ieeexplore.ieee.org/document/9547807}, author = {Enric Perera-Bel and Borja Mercadal and Tomas Garcia-Sanchez and Miguel A. Gonz{\'a}lez-Ballester and Antoni Ivorra} } @article {218, title = {Parametric study of Pulsed Field Ablation with biphasic waveforms in an in vivo heart model: the role of frequency}, journal = {Circulation: Arrhythmia and Electrophysiology}, volume = {15}, year = {2022}, pages = {693-705}, chapter = {693}, doi = {10.1161/CIRCEP.122.010992}, url = {https://www.ahajournals.org/doi/abs/10.1161/CIRCEP.122.010992}, author = {Tomas Garcia-Sanchez and Gerard Amor{\'o}s-Figueras and Esther Jorge and Mar{\'\i}a C. Campos and Elad Maor and Jose M. Guerra and Antoni Ivorra} } @article {224, title = {PIRET {\textemdash} A Platform for Treatment Planning in Electroporation-Based Therapies}, journal = {Transactions on Biomedical Engineering}, volume = {(Accepted)}, year = {2022}, author = {Enric Perera-Bel and Kenneth N. Aycock and Zaid Salameh and Mario G{\'o}mez-Barea and Rafael Davalos and Antoni Ivorra and Miguel A. Gonz{\'a}lez-Ballester} } @article {216, title = {Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents}, journal = {Journal of Neural Engineering}, volume = {19}, year = {2022}, pages = {056015}, chapter = {056015}, doi = {10.1088/1741-2552/ac8dc4}, url = {https://iopscience.iop.org/article/10.1088/1741-2552/ac8dc4}, author = {Aracelys Garc{\'\i}a-Moreno and Albert Comerma and Marc Tudela-Pi and Jesus Minguillon and Laura Becerra-Fajardo and Antoni Ivorra} } @article {206, title = {Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model}, journal = {JACC: Clinical Electrophysiology}, volume = {7}, year = {2021}, pages = {959-964}, chapter = {959}, doi = {10.1016/j.jacep.2021.05.003}, author = {Eyal Heller and Tomas Garcia-Sanchez and Yonatan Moshkovits and Raul Rabinovici and Dvora Grynberg and Amit Segev and Samuel Asirvatham and Antoni Ivorra and Elad Maor} } @conference {211, title = {Injectable Temperature Sensors Based on Passive Rectification of Volume-Conducted Currents}, booktitle = {2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)}, year = {2021}, publisher = {IEEE}, organization = {IEEE}, address = {Berlin, Germany}, doi = {10.1109/BioCAS49922.2021.9645006}, author = {Laura Becerra-Fajardo and Aracelys Garc{\'\i}a-Moreno and Alvarez-De-Eulate, Nerea and Antoni Ivorra} } @article {199, title = {Electrophoresis-assisted accumulation of conductive nanoparticles for the enhancement of cell electropermeabilization}, journal = {Bioelectrochemistry}, volume = {(In Press, Journal Pre-proof)}, year = {2020}, pages = {107642}, chapter = {107642}, doi = {10.1016/j.bioelechem.2020.107642}, url = {https://doi.org/10.1016/j.bioelechem.2020.107642}, author = {Amina Ghorbel and Franck M. Andr{\'e} and Lluis M. Mir and Tomas Garcia-Sanchez} } @article {198, title = {EView: An electric field visualization web platform for electroporation-based therapies}, journal = {Computer Methods and Programs in Biomedicine}, volume = {197}, year = {2020}, pages = {105682}, chapter = {105682}, doi = {10.1016/j.cmpb.2020.105682}, author = {Enric Perera-Bel and Carlos Yag{\"u}e and Borja Mercadal and Mario Ceresa and Natalie Beitel-White and Rafael Davalos and Miguel A. Gonz{\'a}lez-Ballester and Antoni Ivorra} } @article {192, title = {GaN-Based Versatile Waveform Generator for Biomedical Applications of Electroporation}, journal = {IEEE Access}, volume = {(Early Access)}, year = {2020}, doi = {10.1109/ACCESS.2020.2996426}, author = {H{\'e}ctor Sarnago and Jos{\'e} M. Burd{\'\i}o and Tomas Garcia-Sanchez and Lluis M. Mir and Ignacio {\'A}lvarez-Gariburo and {\'O}scar Luc{\'\i}a} } @article {185, title = {High-voltage pulsed electric field laboratory device with asymmetric voltage multiplier for marine macroalgae electroporation}, journal = {Innovative Food Science and Emerging Technologies}, volume = {(In press, Journal Pre-proof)}, year = {2020}, doi = {10.1016/j.ifset.2020.102288}, author = {Klimentiy Levkov and Yoav Linzon and Borja Mercadal and Antoni Ivorra and C{\'e}sar Gonz{\'a}lez and Alexander Golberg} } @article {193, title = {Injectable Sensors Based on Passive Rectification of Volume-Conducted Currents}, journal = {IEEE Transactions on Biomedical Circuits and Systems}, volume = {14}, year = {2020}, pages = {867-878}, chapter = {867}, doi = {10.1109/TBCAS.2020.3002326}, url = {https://ieeexplore.ieee.org/document/9117042}, author = {Shahid Malik and Q. Castellv{\'\i} and Laura Becerra-Fajardo and Marc Tudela-Pi and Aracelys Garc{\'\i}a-Moreno and Maryam Shojaei Baghini and Antoni Ivorra} } @article {194, title = {Monitoring the molecular composition of live cells exposed to electric pulses via label-free optical methods}, journal = {Scientific Reports}, volume = {10}, year = {2020}, pages = {10471}, chapter = {10471}, doi = {10.1038/s41598-020-67402-x}, url = {https://doi.org/10.1038/s41598-020-67402-x}, author = {Antoine Azan and Marianne Grognot and Tomas Garcia-Sanchez and Lucie Descamps and Val{\'e}rie Untereiner and Guilhem Gallot and Lluis M. Mir} } @article {197, title = {Physiological changes may dominate the electrical properties of liver during reversible electroporation: measurements and modelling}, journal = {Bioelectrochemistry}, volume = {(In Press, Journal Pre-proof)}, year = {2020}, doi = {10.1016/j.bioelechem.2020.107627}, url = {https://doi.org/10.1016/j.bioelechem.2020.107627}, author = {Tomas Garcia-Sanchez and Damien Voyer and Clair Poignard and Lluis M. Mir} } @article {191, title = {Possible molecular and cellular mechanisms at the basis of atmospheric electromagnetic field bioeffects}, journal = {International Journal of Biometeorology}, volume = {(In Press, available online)}, year = {2020}, doi = {10.1007/s00484-020-01885-1}, url = {https://doi.org/10.1007/s00484-020-01885-1}, author = {Michal Cifra and Francesca Apollonio and Micaela Liberti and Tomas Garcia-Sanchez and Lluis M. Mir} } @article {189, title = {Power Transfer by Volume Conduction: In Vitro Validated Analytical Models Predict DC Powers above 1 mW in Injectable Implants}, journal = {IEEE Access}, volume = {8}, year = {2020}, pages = {37808-37820}, chapter = {37808}, doi = {10.1109/ACCESS.2020.2975597}, author = {Marc Tudela-Pi and Laura Becerra-Fajardo and Aracelys Garc{\'\i}a-Moreno and Jesus Minguillon and Antoni Ivorra} } @article {180, title = {The combination of electroporation and electrolysis (E2) employing different electrode arrays for ablation of large tissue volumes}, journal = {PLoS One}, volume = {14}, year = {2019}, pages = {e0221393}, chapter = {e0221393}, doi = {10.1371/journal.pone.0221393}, url = {https://doi.org/10.1371/journal.pone.0221393}, author = {Nina Klein and Enric Guenther and Florin Botea and Mihail Pautov and Simona Dima and Dana Tomescu and Mihai Popescu and Antoni Ivorra and Michael Stehling and Irinel Popescu} } @article {186, title = {Industrial Electronics for Biomedicine: A New Cancer Treatment Using Electroporation}, journal = {IEEE Industrial Electronics Magazine}, volume = {13}, year = {2019}, pages = {6-18}, chapter = {6}, doi = {10.1109/MIE.2019.2942377}, author = {{\'O}scar Luc{\'\i}a and H{\'e}ctor Sarnago and Tomas Garcia-Sanchez and Lluis M. Mir and Jos{\'e} M. Burd{\'\i}o} } @article {179, title = {Successful tumor Electrochemotherapy using Sine Waves}, journal = {IEEE Transactions on Biomedical Engineering}, volume = {67}, year = {2019}, pages = {1040-1049}, chapter = {1040}, doi = {10.1109/TBME.2019.2928645}, author = {Tomas Garcia-Sanchez and Borja Mercadal and Melanie Polrot and Adeline Muscat and H{\'e}ctor Sarnago and {\'O}scar Luc{\'\i}a and Lluis M. Mir} } @article {162, title = {Numerical analysis of thermal impact of intramyocardial capillary blood flow during radiofrequency cardiac ablation}, journal = {International Journal of Hyperthermia}, volume = {34}, year = {2018}, pages = {243-249}, chapter = {243}, doi = {10.1080/02656736.2017.1336258}, author = {P{\'e}rez, Juan J. and Gonz{\'a}lez-Su{\'a}rez, Ana and Berjano, Enrique} } @article {167, title = {Relation between Denaturation Time Measured by Optical Coherence Reflectometry and Thermal Lesion Depth during Radiofrequency Cardiac Ablation: Feasibility Numerical Study}, journal = {Lasers in surgery and medicine}, volume = {50}, year = {2018}, pages = {222-229}, chapter = {222}, doi = {10.1002/lsm.22771}, author = {Gonz{\'a}lez-Su{\'a}rez, Ana and Herranz, David and Berjano, Enrique and Rubio-Guivernau, Jose L and Margallo-Balb{\'a}s, Eduardo} } @article {183, title = {RF-Energized Intracoronary Guidewire to Enhance Bipolar Ablation of the Interventricular Septum: In-silico Feasibility Study}, journal = {International Journal of Hyperthermia}, volume = {34}, year = {2018}, pages = {1202-1212}, chapter = {1202}, doi = {10.1080/02656736.2018.1425487}, url = {https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1425487}, author = {P{\'e}rez, Juan J. and Gonz{\'a}lez-Su{\'a}rez, Ana and d{\textquoteright}Avila, A and Berjano, Enrique} } @article {182, title = {Should fluid dynamics be included in computer models of RF cardiac ablation by irrigated-tip electrodes?}, journal = {BioMedical Engineering OnLine}, volume = {17}, year = {2018}, pages = {43}, chapter = {43}, doi = {10.1186/s12938-018-0475-7}, url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910590/}, author = {Gonz{\'a}lez-Su{\'a}rez, Ana and P{\'e}rez, Juan J. and Berjano, Enrique} } @article {166, title = {Focused Transhepatic Electroporation Mediated by Hypersaline Infusion throuth the Portal Vein in Rat Model. Preliminary Results on Differential Conductivity}, journal = {Radiology and Oncology}, volume = {51}, year = {2017}, pages = {415-421}, chapter = {415}, author = {Clara Pa{\~n}ella and Q. Castellv{\'\i} and Xavier Moll and Rita Quesada and Alberto Villanueva and M. Iglesias and Dolores Naranjo and Patricia S{\'a}nchez-Vel{\'a}zquez and Andaluz, Anna and Luis Grande and Antoni Ivorra and Burd{\'\i}o, Fernando} } @conference {156, title = {Injectable Stimulators Based on Rectification of High Frequency Current Bursts: Power Efficiency of 2~mm Thick Prototypes}, booktitle = {Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation (ICNR2016), October 18-21, 2016, Segovia, Spain}, year = {2017}, publisher = {Springer International Publishing}, organization = {Springer International Publishing}, address = {Cham}, abstract = {

To overcome the miniaturization bottleneck imposed by existing power generation/transfer technologies for implantable stimulators, we have proposed a heterodox electrical stimulation method based on local rectification of high frequency (>=1\ MHz) current bursts delivered through superficial electrodes. We have reported 2\ mm thick addressable injectable stimulators, made of off-the-shelf components, that operate according to this principle. Since a significant amount of high frequency power is wasted by Joule heating, the method exhibits poor energy efficiency. In here we have performed a numerical case study in which the presence of the above implant prototypes is simulated in an anatomically realistic leg model. The results from this study indicate that, despite low power transfer efficiency (~0.05\ \%), the power consumed by the external high frequency current generator is low enough (\<4\ W) to grant the use of small portable batteries.

}, isbn = {978-3-319-46669-9}, doi = {10.1007/978-3-319-46669-9_110}, url = {http://dx.doi.org/10.1007/978-3-319-46669-9_110}, author = {Laura Becerra-Fajardo and Garcia-Arnau, Roser and Antoni Ivorra}, editor = {Ib{\'a}{\~n}ez, Jaime and Gonz{\'a}lez-Vargas, Jos{\'e} and Azor{\'\i}n, Jos{\'e} Mar{\'\i}a and Akay, Metin and Pons, Jos{\'e} Luis} } @article {158, title = {Long-term effectiveness of irreversible electroporation in a murine model of colorectal liver metastasis}, journal = {Scientific reports}, volume = {7}, year = {2017}, chapter = {44821}, doi = {10.1038/srep44821}, author = {Patricia S{\'a}nchez-Vel{\'a}zquez and Q. Castellv{\'\i} and Alberto Villanueva and M. Iglesias and Rita Quesada and Clara Pa{\~n}ella and Marta C{\'a}ceres and Dimitri Dorcaratto and Andaluz, Anna and Xavier Moll and Jos{\'e} M. Burd{\'\i}o and Luis Grande and Antoni Ivorra and Burd{\'\i}o, Fernando} } @article {150, title = {Irreversible electroporation of the liver: is there a safe limit to the ablation volume?}, journal = {Scientific Reports}, volume = {6}, year = {2016}, pages = {23781}, doi = {10.1038/srep23781}, author = {Patricia S{\'a}nchez-Vel{\'a}zquez and Q. Castellv{\'\i} and Alberto Villanueva and Rita Quesada and Clara Pa{\~n}ella and Marta C{\'a}ceres and Dimitri Dorcaratto and Andaluz, Anna and Xavier Moll and Trujillo, Macarena and Jos{\'e} M. Burd{\'\i}o and Berjano, Enrique and Luis Grande and Antoni Ivorra and Burd{\'\i}o, Fernando} } @article {137, title = {Tumor growth delay by adjuvant alternating electric fields which appears non-thermally mediated}, journal = {Bioelectrochemistry}, volume = {105}, year = {2015}, month = {2015/10//}, pages = {16 - 24}, keywords = {Alternating electric field, Chemotherapeutic adjuvant, Hyperthermia, Pancreatic tumor, TTFields}, isbn = {1567-5394}, doi = {10.1016/j.bioelechem.2015.04.006}, author = {Q. Castellv{\'\i} and Mireia M. Ginest{\`a} and G. Capella and Antoni Ivorra} } @article {Gonzalez-Sosa2014, title = {{Fast flow-through non-thermal pasteurization using constant radiofrequency electric fields}}, journal = {Innovative Food Science and Emerging Technologies}, volume = {22}, year = {2014}, pages = {pp.116-123}, chapter = {116}, doi = {DOI: 10.1016/j.ifset.2014.01.003}, author = {J. Gonz{\'a}lez-Sosa and A. Ruiz-Vargas and G. Arias and Antoni Ivorra} } @conference {Gonzalez-Sosa2013, title = {{Fast flow-through non-thermal pasteurization using constant radiofrequency electric fields}}, booktitle = {Tenth International Bioelectrics Symposium (BIOELECTRICS 2013)}, year = {2013}, address = {Karlsruhe, Germany}, abstract = {

Pulsed Electric Field technologies have captured the attention of researchers on food pasteurization because of their non-thermal inactivation mechanism, which results in fresh-like products. Nevertheless, high voltage pulsing required by these technologies implies complex and costly generators. Here, as an alternative, it is proposed a method, partially inherited from research on cell electroporation for gene transfection, in which the liquid to be treated flows at high speed through a miniature chamber where the electric field is permanently applied. In particular, it is proposed that the constantly applied electric field consists of an AC signal (\> 100 kHz) so that electrochemical by-products are minimized. The method, while being compatible with batch processing, will allow use of lower voltages and will avoid the pulsation requirement.\ 

}, author = {J. Gonz{\'a}lez-Sosa and A. Ruiz-Vargas and G. Arias and Q. Castellv{\'\i} and Antoni Ivorra} } @article {142, title = {In vivo assessment of corneal barrier function through non-invasive impedance measurements using a flexible probe}, journal = {Journal of Physics: Conference Series}, volume = {434}, year = {2013}, pages = {012072}, abstract = {

The cornea is a transparent structure composed of three layers: the epithelium, the stroma and the endothelium. To maintain its ransparency the stroma remains in a constant state of dehydration. Consequently, any ion flow disorder through the covering layers can compromise the barrier function and, therefore the corneal homeostasis. Since ionic permeability has a fundamental impact on the passive electrical properties of living tissues, in this work it is proposed and demonstrated a diagnosis method based on tetrapolar impedance measurements performed by electrodes placed on the corneal surface. The contribution of each cornea layer to the total measured impedance has been analysed over a frequency range. Following the obtained guidelines, a flexible probe with integrated electrodes has been developed and manufactured using SU-8 photoresin. The feasibility of the proposed method has been evaluated in vivo by monitoring corneal epithelium wound healing. Obtained impedance measurements have been compared with measurements of permeability to sodium fluorescein from different excised corneas. Successful results demonstrate the feasibility of this novel flexible sensor and its capability to quantify corneal permeability in vivo in a noninvasive way.

}, url = {http://stacks.iop.org/1742-6596/434/i=1/a=012072}, author = {A Guimera and X Illa and E Traver and S Marchan and C Herrero and C Lagunas and M J Maldonado and Antoni Ivorra and R Villa} } @conference {Castellvi2013, title = {{In vivo study using Tumor Treatment Fields (TTFs) and prolonged mild hyperthermia as adjuvant methods for cancer treatment}}, booktitle = {Tenth International Bioelectrics Symposium (BIOELECTRICS 2013)}, year = {2013}, address = {Karlsruhe, Germany}, abstract = {

Delivery of the so called Tumor Treatment Fields (TTFs) was proposed a few years ago as a cancer therapy and has been object of study in a recent phase III trial in which their efficacy against glioblastomas was assessed with modest results [1]. TTFs are alternating electric fields at a frequency in the order of 100 kHz and a magnitude below 300 V/m which are applied continuously for weeks. According to their proposers, TTFs inhibit tumor growth by interfering with the cell division process through electrical forces without causing significant heating in tissues. However, we estimate that TTFs are capable of producing temperature increases of about some tens of kelvin which cannot be neglected, particularly because TTFs are applied for long periods of time. Therefore, we hypothesized that the promising results reported in initial in vitro and in vivo studies on the use of TTFs could be mediated by heat rather than by electrical forces. Heat induction (i.e. hyperthermia) has been extensively used as an adjuvant in cancer treatment. Typically, cancer hyperthermia involves generating moderate temperature increases during about one hour after radiotherapy or chemotherapy sessions. Nevertheless, to the best of our knowledge, there are no in vivo studies on the use of mild hyperthermia for long periods of time, despite there are in vitro studies showing that cell survival to hyperthermia depends both on the temperature and the exposition time. In order to test our hypothesis and also to independently validate the efficacy of TTFs, we have carried out a study in which nude mice subcutaneously implanted with human exocrine pancreatic adenocarcinomas were physically treated for 7 days; either with heat from a resistor or with TTFs delivered by electrodes. The animals were paired: one was treated and the other was sham treated. Four treatment groups were created: hyperthermia (H) (n=5+5), hyperthermia + gemcitabine chemotherapy (H\&Ch) (n=6+6), TTFs (TTF) (n=5+5) and TTFs + gemcitabine therapy (TTF\&Ch) (n=7+7). Our hypothesis has not been validated: no statistically significant effects were observed in the H and H\&Ch groups. On the other hand, although the TTF group did also not produce any significant effect, the animals treated with the TTFs + chemotherapy combination show a tumor growth rate about 200\% smaller (p=0.018) than the animals treated only with chemotherapy.

}, author = {Q. Castellv{\'\i} and Mireia M. Ginest{\`a} and G. Capella and Antoni Ivorra} } @article {Guimera2010, title = {{Non-invasive assessment of corneal endothelial permeability by means of electrical impedance measurements.}}, journal = {Medical engineering \& physics}, volume = {32}, number = {10}, year = {2010}, pages = {1107{\textendash}15. {\textcopyright} 2010 IPEM. Published by Elsevier Ltd.}, abstract = {

The permeability of the corneal endothelial layer has an important role in the correct function of the cornea. Since ionic permeability has a fundamental impact on the passive electrical properties of living tissues, here it is hypothesized that impedance methods can be employed for assessing the permeability of the endothelial layer in a minimally invasive fashion. Precisely, the main objective of the present study is to develop and to analyze a minimally invasive method for assessing the electrical properties of the corneal endothelium, as a possible diagnostic tool for the evaluation of patients with endothelial dysfunction. A bidimensional model consisting of the main corneal layers and a four-electrode impedance measurement setup placed on the epithelium has been implemented and analyzed by means of the finite elements method (FEM). In order to obtain a robust indicator of the permeability of the endothelium layer, the effect of the endothelium electrical properties on the measured impedance has been studied together with reasonable variations of the other model layers. Simulation results show that the impedance measurements by means of external electrodes are indeed sufficiently sensitive to the changes in the electrical properties of the endothelial layer. It is concluded that the method presented here can be employed as non-invasive method for assessing endothelial layer function.

}, keywords = {Biomedical Engineering, Biomedical Engineering: methods, Corneal, Corneal: abnormalities, Corneal: metabolism, Corneal: pathology, Electric Impedance, Electric Impedance: diagnostic use, Endothelium, Finite Element Analysis, Humans, Permeability, Reproducibility of Results, Sensitivity and Specificity}, issn = {1873-4030}, doi = {10.1016/j.medengphy.2010.07.016}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20832346}, author = {A Guimera and Antoni Ivorra and Gabriel, G and R Villa} }