@article {245, title = {Angiographic and histological characterization of PFA-induced coronary spasm: Differential effect of two waveforms}, journal = {Heart Rhythm}, volume = {(In Press, Journal Pre-proof)}, year = {2026}, doi = {10.1016/j.hrthm.2026.03.1904}, url = {https://doi.org/10.1016/j.hrthm.2026.03.1904}, author = {Gerard Amor{\'o}s-Figueras and Q. Castellv{\'\i} and Sergi Casabella-Ramon and Marc Soriano-Amores and {\'A}lvaro Borachok and del Pino, Pablo and Zoraida Moreno-Weidmann and Antoni Ivorra and Jose M. Guerra} } @article {238, title = {Atrial fibrillation and flutter conversion with pulsed electric field delivery: preclinical proof of concept}, journal = {Journal of Interventional Cardiac Electrophysiology}, year = {2025}, doi = {10.1007/s10840-025-02115-7}, url = {https://doi.org/10.1007/s10840-025-02115-7}, author = {Tan, Nicholas Y. and Del-Carpio-Munoz, Freddy and Tri, Jason A. and Taro Koya and Naoto Otsuka and DeSimone, Christopher V. and Suraj Yalamuri and Elad Maor and Q. Castellv{\'\i} and Antoni Ivorra and Damijan Miklav{\v c}i{\v c} and Samuel Asirvatham} } @article {240, title = {The Biomedical Engineer{\textquoteright}s Pledge: Overview and Context}, journal = {Medical \& Biological Engineering \& Computing}, volume = {(Published online)}, year = {2025}, doi = {10.1007/s11517-025-03443-6}, url = {https://doi.org/10.1007/s11517-025-03443-6}, author = {Antoni Ivorra and Txetxu Aus{\'\i}n and Laura Becerra-Fajardo and del Ama, Antonio J. and Jesus Minguillon and Aracelys Garc{\'\i}a-Moreno and Jordi Aguil{\'o} and Filipe O. Barroso and Bijnens, Bart and Oscar Camara and Sara Capdevila and Castellanos-Fernandez, Roger and Rafael Davalos and Jean-Louis Divoux and Ahmed Eladly and Dario Farina and Garc{\'\i}a-Hombravella, Carla and Gonz{\'a}lez-L{\'o}pez, Raquel and C{\'e}sar Gonz{\'a}lez and Jordi Gr{\'\i}fols and Felipe Maglietti and Shahid Malik and Elad Maor and Guillermo Marshall and Mateu-Yus, Berta and Lluis M. Mir and Moreno, Juan C. and Xavier Navarro and N{\'u}ria Noguera and Andr{\'e}s Ozaita and Gemma Piella and Pons, Jos{\'e} Luis and Rita Quesada and Pilar Rivera-Gil and Boris Rubinsky and Ruiz-Garcia, Aurelio and Ruiz-Vargas, Albert and S{\'a}nchez-S{\'a}nchez, Maria and Andreas Schneider and Ting Shu and Villa-Sanz, Rosa and Bing Zhang and Gema Revuelta} } @article {243, title = {Local modifications in tissular conditions before PFA increases acute lesion size}, journal = {Heart Rhythm O2}, volume = {(In press)}, year = {2025}, doi = {10.1016/j.hroo.2025.11.021 }, url = {https://www.heartrhythmopen.com/article/S2666-5018(25)00567-7/fulltext}, author = {Gerard Amor{\'o}s-Figueras and Sergi Casabella-Ramon and Zoraida Moreno-Weidmann and Q. Castellv{\'\i} and Antoni Ivorra and Tomas Garcia-Sanchez and Jose M. Guerra} } @article {233, title = {Is a single lethal electric field threshold sufficient to characterize the lesion size in computational modeling of cardiac pulsed field ablation?}, journal = {Heart Rhythm O2}, volume = {6}, year = {2025}, pages = {671-677}, chapter = {671}, doi = {10.1016/j.hroo.2025.02.014}, url = {https://doi.org/10.1016/j.hroo.2025.02.014}, author = {Argyrios Petras and Gerard Amor{\'o}s-Figueras and Zoraida Moreno-Weidmann and Tomas Garcia-Sanchez and David Vilad{\'e}s Medel and Antoni Ivorra and Jose M. Guerra and Luca Gerardo-Giorda} } @article {231, title = {Changes in local endocardial electrograms immediately after PFA show dose-dependent variations}, journal = {EP Europace}, volume = {26}, year = {2024}, pages = {euae102.755}, chapter = {euae102.755}, doi = {10.1093/europace/euae102.755}, url = {https://academic.oup.com/europace/article/26/Supplement_1/euae102.755/7681509}, author = {Gerard Amor{\'o}s-Figueras and Zoraida Moreno-Weidmann and Sergi Casabella-Ramon and Antoni Ivorra and Jose M. Guerra and Tomas Garcia-Sanchez} } @article {228, title = {Effects of Contact Force on Lesion Size During Pulsed Field Catheter Ablation: Histochemical Characterization of Ventricular Lesion Boundaries}, journal = {Circulation: Arrhythmia and Electrophysiology}, volume = {17}, year = {2024}, pages = {e012026}, chapter = {e012026}, doi = {10.1161/CIRCEP.123.012026}, url = {https://doi.org/10.1161/CIRCEP.123.012026}, author = {Hiroshi Nakagawa and Q. Castellv{\'\i} and Robert Neal and Steven Girouard and Jacob Laughner and Atsushi Ikeda and Masafumi Sugawara and Yoshimori An and Hussein, Ayman A. and Shady Nakhla and Tyler Taigen and Jakub Srounbek and Mohamed Kanj and Pasquale Santangeli and Walid I. Saliba and Antoni Ivorra and Oussama M. Wazni} } @article {226, title = {Dynamics of High-Density Unipolar Epicardial Electrograms During PFA}, journal = {Circulation: Arrhythmia and Electrophysiology}, year = {2023}, pages = {e011914}, chapter = {e011914}, doi = {10.1161/CIRCEP.123.011914}, url = {https://www.ahajournals.org/doi/10.1161/CIRCEP.123.011914}, author = {Gerard Amor{\'o}s-Figueras and Sergi Casabella-Ramon and Zoraida Moreno-Weidmann and Antoni Ivorra and Jose M. Guerra and Tomas Garcia-Sanchez} } @article {218, title = {Parametric study of Pulsed Field Ablation with biphasic waveforms in an in vivo heart model: the role of frequency}, journal = {Circulation: Arrhythmia and Electrophysiology}, volume = {15}, year = {2022}, pages = {693-705}, chapter = {693}, doi = {10.1161/CIRCEP.122.010992}, url = {https://www.ahajournals.org/doi/abs/10.1161/CIRCEP.122.010992}, author = {Tomas Garcia-Sanchez and Gerard Amor{\'o}s-Figueras and Esther Jorge and Mar{\'\i}a C. Campos and Elad Maor and Jose M. Guerra and Antoni Ivorra} } @article {224, title = {PIRET {\textemdash} A Platform for Treatment Planning in Electroporation-Based Therapies}, journal = {Transactions on Biomedical Engineering}, volume = {(Accepted)}, year = {2022}, author = {Enric Perera-Bel and Kenneth N. Aycock and Zaid Salameh and Mario G{\'o}mez-Barea and Rafael Davalos and Antoni Ivorra and Miguel A. Gonz{\'a}lez-Ballester} } @article {206, title = {Comparing High-Frequency With Monophasic Electroporation Protocols in an In Vivo Beating Heart Model}, journal = {JACC: Clinical Electrophysiology}, volume = {7}, year = {2021}, pages = {959-964}, chapter = {959}, doi = {10.1016/j.jacep.2021.05.003}, author = {Eyal Heller and Tomas Garcia-Sanchez and Yonatan Moshkovits and Raul Rabinovici and Dvora Grynberg and Amit Segev and Samuel Asirvatham and Antoni Ivorra and Elad Maor} } @conference {211, title = {Injectable Temperature Sensors Based on Passive Rectification of Volume-Conducted Currents}, booktitle = {2021 IEEE Biomedical Circuits and Systems Conference (BioCAS)}, year = {2021}, publisher = {IEEE}, organization = {IEEE}, address = {Berlin, Germany}, doi = {10.1109/BioCAS49922.2021.9645006}, author = {Laura Becerra-Fajardo and Aracelys Garc{\'\i}a-Moreno and Alvarez-De-Eulate, Nerea and Antoni Ivorra} } @article {187, title = {Dynamics of Cell Death After Conventional IRE and H-FIRE Treatments}, journal = {Annals of Biomedical Engineering}, volume = {48}, year = {2020}, pages = {1451{\textendash}1462}, chapter = {pages1451}, doi = {10.1007/s10439-020-02462-8}, url = {https://doi.org/10.1007/s10439-020-02462-8}, author = {Borja Mercadal and Natalie Beitel-White and Kenneth N. Aycock and Q. Castellv{\'\i} and Rafael Davalos and Antoni Ivorra} } @article {199, title = {Electrophoresis-assisted accumulation of conductive nanoparticles for the enhancement of cell electropermeabilization}, journal = {Bioelectrochemistry}, volume = {(In Press, Journal Pre-proof)}, year = {2020}, pages = {107642}, chapter = {107642}, doi = {10.1016/j.bioelechem.2020.107642}, url = {https://doi.org/10.1016/j.bioelechem.2020.107642}, author = {Amina Ghorbel and Franck M. Andr{\'e} and Lluis M. Mir and Tomas Garcia-Sanchez} } @article {192, title = {GaN-Based Versatile Waveform Generator for Biomedical Applications of Electroporation}, journal = {IEEE Access}, volume = {(Early Access)}, year = {2020}, doi = {10.1109/ACCESS.2020.2996426}, author = {H{\'e}ctor Sarnago and Jos{\'e} M. Burd{\'\i}o and Tomas Garcia-Sanchez and Lluis M. Mir and Ignacio {\'A}lvarez-Gariburo and {\'O}scar Luc{\'\i}a} } @article {194, title = {Monitoring the molecular composition of live cells exposed to electric pulses via label-free optical methods}, journal = {Scientific Reports}, volume = {10}, year = {2020}, pages = {10471}, chapter = {10471}, doi = {10.1038/s41598-020-67402-x}, url = {https://doi.org/10.1038/s41598-020-67402-x}, author = {Antoine Azan and Marianne Grognot and Tomas Garcia-Sanchez and Lucie Descamps and Val{\'e}rie Untereiner and Guilhem Gallot and Lluis M. Mir} } @article {191, title = {Possible molecular and cellular mechanisms at the basis of atmospheric electromagnetic field bioeffects}, journal = {International Journal of Biometeorology}, volume = {(In Press, available online)}, year = {2020}, doi = {10.1007/s00484-020-01885-1}, url = {https://doi.org/10.1007/s00484-020-01885-1}, author = {Michal Cifra and Francesca Apollonio and Micaela Liberti and Tomas Garcia-Sanchez and Lluis M. Mir} } @article {169, title = {Avoiding neuromuscular stimulation in liver irreversible electroporation using radiofrequency electric fields}, journal = {Physics in Medicine and Biology}, volume = {63}, year = {2018}, pages = {035027}, chapter = {035027}, doi = {10.1088/1361-6560/aaa16f}, author = {Q. Castellv{\'\i} and Borja Mercadal and Xavier Moll and Fontdevila, Dolors and Andaluz, Anna and Antoni Ivorra} } @article {174, title = {Design, Construction and Validation of an Electrical Impedance Probe with Contact Force and Temperature Sensors Suitable for in-vivo Measurements}, journal = {Scientific Reports}, volume = {8}, year = {2018}, pages = {14818}, chapter = {14818}, doi = {10.1038/s41598-018-33221-4}, author = {A. Ruiz-Vargas and Antoni Ivorra and J. W. Arkwright} } @article {168, title = {Impedance spectroscopy measurements as a tool for distinguishing different luminal content during bolus transit studies}, journal = {Neurogastroenterology and Motility}, volume = {30}, year = {2018}, pages = {e13274}, chapter = {e13274}, doi = {10.1111/nmo.13274}, author = {A. Ruiz-Vargas and R. Mohd Rosli and Antoni Ivorra and J. W. Arkwright} } @article {171, title = {Irreversible electroporation for the treatment of cardiac arrhythmias}, journal = {Expert Review of Cardiovascular Therapy}, volume = {16}, year = {2018}, pages = {349-360 }, chapter = {349}, doi = {10.1080/14779072.2018.1459185}, url = {https://www.tandfonline.com/doi/abs/10.1080/14779072.2018.1459185}, author = {Alan Sugrue and Elad Maor and Antoni Ivorra and Vaibhav Vaidya and Chance Witt and Suraj Kapa and Samuel Asirvatham} } @article {161, title = {Modeling Liver Electrical Conductivity during Hypertonic Injection}, journal = {International Journal for Numerical Methods in Biomedical Engineering}, volume = {34}, year = {2018}, pages = {e2904}, chapter = {e2904}, doi = {10.1002/cnm.2904}, author = {Q. Castellv{\'\i} and Patricia S{\'a}nchez-Vel{\'a}zquez and Xavier Moll and Berjano, Enrique and Andaluz, Anna and Burd{\'\i}o, Fernando and Bijnens, Bart and Antoni Ivorra} } @conference {181, title = {Monitoring the Effect of Contact Pressure on Bioimpedance Measurements}, booktitle = {018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)}, year = {2018}, month = {2019}, pages = {4949-4952}, doi = {10.1109/EMBC.2018.8513173}, author = {A. Ruiz-Vargas and Antoni Ivorra and J. W. Arkwright} } @article {153, title = {Anatomically Realistic Simulations of Liver Ablation by Irreversible Electroporation: Impact of Blood Vessels on Ablation Volumes and Undertreatment}, journal = {Technology in Cancer Research \& Treatment}, volume = {[Epub ahead of print]}, year = {2017}, doi = {10.1177/1533034616687477}, author = {Radwan Qasrawi and Louis Silve and Fernando Burd{\'\i}o and Ziad Abdeen and Antoni Ivorra} } @article {165, title = {Avoiding nerve stimulation in irreversible electroporation: a numerical modeling study}, journal = {Physics in Medicine and Biology}, volume = {62}, year = {2017}, pages = {8060-8079}, chapter = {8060}, doi = {https://doi.org/10.1088/1361-6560/aa8c53}, author = {Borja Mercadal and Christopher Arena and Rafael Davalos and Antoni Ivorra} } @article {166, title = {Focused Transhepatic Electroporation Mediated by Hypersaline Infusion throuth the Portal Vein in Rat Model. Preliminary Results on Differential Conductivity}, journal = {Radiology and Oncology}, volume = {51}, year = {2017}, pages = {415-421}, chapter = {415}, author = {Clara Pa{\~n}ella and Q. Castellv{\'\i} and Xavier Moll and Rita Quesada and Alberto Villanueva and M. Iglesias and Dolores Naranjo and Patricia S{\'a}nchez-Vel{\'a}zquez and Andaluz, Anna and Luis Grande and Antoni Ivorra and Burd{\'\i}o, Fernando} } @conference {156, title = {Injectable Stimulators Based on Rectification of High Frequency Current Bursts: Power Efficiency of 2~mm Thick Prototypes}, booktitle = {Converging Clinical and Engineering Research on Neurorehabilitation II: Proceedings of the 3rd International Conference on NeuroRehabilitation (ICNR2016), October 18-21, 2016, Segovia, Spain}, year = {2017}, publisher = {Springer International Publishing}, organization = {Springer International Publishing}, address = {Cham}, abstract = {

To overcome the miniaturization bottleneck imposed by existing power generation/transfer technologies for implantable stimulators, we have proposed a heterodox electrical stimulation method based on local rectification of high frequency (>=1\ MHz) current bursts delivered through superficial electrodes. We have reported 2\ mm thick addressable injectable stimulators, made of off-the-shelf components, that operate according to this principle. Since a significant amount of high frequency power is wasted by Joule heating, the method exhibits poor energy efficiency. In here we have performed a numerical case study in which the presence of the above implant prototypes is simulated in an anatomically realistic leg model. The results from this study indicate that, despite low power transfer efficiency (~0.05\ \%), the power consumed by the external high frequency current generator is low enough (\<4\ W) to grant the use of small portable batteries.

}, isbn = {978-3-319-46669-9}, doi = {10.1007/978-3-319-46669-9_110}, url = {http://dx.doi.org/10.1007/978-3-319-46669-9_110}, author = {Laura Becerra-Fajardo and Garcia-Arnau, Roser and Antoni Ivorra}, editor = {Ib{\'a}{\~n}ez, Jaime and Gonz{\'a}lez-Vargas, Jos{\'e} and Azor{\'\i}n, Jos{\'e} Mar{\'\i}a and Akay, Metin and Pons, Jos{\'e} Luis} } @article {158, title = {Long-term effectiveness of irreversible electroporation in a murine model of colorectal liver metastasis}, journal = {Scientific reports}, volume = {7}, year = {2017}, chapter = {44821}, doi = {10.1038/srep44821}, author = {Patricia S{\'a}nchez-Vel{\'a}zquez and Q. Castellv{\'\i} and Alberto Villanueva and M. Iglesias and Rita Quesada and Clara Pa{\~n}ella and Marta C{\'a}ceres and Dimitri Dorcaratto and Andaluz, Anna and Xavier Moll and Jos{\'e} M. Burd{\'\i}o and Luis Grande and Antoni Ivorra and Burd{\'\i}o, Fernando} } @article {150, title = {Irreversible electroporation of the liver: is there a safe limit to the ablation volume?}, journal = {Scientific Reports}, volume = {6}, year = {2016}, pages = {23781}, doi = {10.1038/srep23781}, author = {Patricia S{\'a}nchez-Vel{\'a}zquez and Q. Castellv{\'\i} and Alberto Villanueva and Rita Quesada and Clara Pa{\~n}ella and Marta C{\'a}ceres and Dimitri Dorcaratto and Andaluz, Anna and Xavier Moll and Trujillo, Macarena and Jos{\'e} M. Burd{\'\i}o and Berjano, Enrique and Luis Grande and Antoni Ivorra and Burd{\'\i}o, Fernando} } @article {141, title = {Comparison of the effects of the repetition rate between microsecond and nanosecond pulses: Electropermeabilization-induced electro-desensitization?}, journal = {Biochimica et Biophysica Acta (BBA) - General Subjects}, volume = {1840}, year = {2014}, pages = {2139 - 2151}, keywords = {Electroporation}, issn = {0304-4165}, doi = {http://dx.doi.org/10.1016/j.bbagen.2014.02.011}, url = {http://www.sciencedirect.com/science/article/pii/S0304416514000725}, author = {Aude Silve and A. Guimer{\`a} Brunet and B. Al-Sakere and Antoni Ivorra and L.M. Mir} } @article {Gonzalez-Sosa2014, title = {{Fast flow-through non-thermal pasteurization using constant radiofrequency electric fields}}, journal = {Innovative Food Science and Emerging Technologies}, volume = {22}, year = {2014}, pages = {pp.116-123}, chapter = {116}, doi = {DOI: 10.1016/j.ifset.2014.01.003}, author = {J. Gonz{\'a}lez-Sosa and A. Ruiz-Vargas and G. Arias and Antoni Ivorra} } @article {Trujillo2013, title = {{Can electroporation previous to radiofrequency hepatic ablation enlarge thermal lesion size? A feasibility study based on theoretical modelling and in vivo experiments.}}, journal = {International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group}, volume = {29}, number = {3}, year = {2013}, pages = {211{\textendash}8. {\textcopyright} 2013 Informa UK Ltd.}, abstract = {

PURPOSE: The aim of this study was to assess the feasibility of a hybrid ablative technique based on applying electroporation (EP) pulses just before conducting radiofrequency ablation (RFA). The rationale was that the EP-induced reduction in blood perfusion could be sufficient to reduce the thermal sink effect and hence to increase the coagulation volume in comparison to that created exclusively by RFA. MATERIALS AND METHODS: A modelling study and in vivo experimental study were used. A Cool-tip RF applicator was used both for EP and RFA. RESULTS: Overall, the results did not show any synergy effect from using the hybrid technique. Applying EP pulses prior to RFA did not increase the coagulation zone obtained and the lesions were almost identical. Additional computer simulations provided an explanation for this; the effect of reducing blood perfusion by thermal damage during RFA completely masks the effect of reducing blood perfusion by EP. This is because both thermal damage and EP affect the same zone, i.e. the tissue around the electrode. CONCLUSIONS: Our computer modelling and in vivo experimental findings suggest that the combination of EP and RFA with monopolar applicators does not provide an additional benefit over the use of RFA alone.

}, keywords = {Animals, Catheter Ablation, Combined Modality Therapy, Computer Simulation, Electroporation, Feasibility Studies, Female, Liver, Liver: surgery, Models, Swine, Theoretical}, issn = {1464-5157}, doi = {10.3109/02656736.2013.777854}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23573935}, author = {Trujillo, Macarena and Q. Castellv{\'\i} and Burd{\'\i}o, Fernando and Patricia S{\'a}nchez-Vel{\'a}zquez and Antoni Ivorra and Andaluz, Anna and Berjano, Enrique} } @conference {Gonzalez-Sosa2013, title = {{Fast flow-through non-thermal pasteurization using constant radiofrequency electric fields}}, booktitle = {Tenth International Bioelectrics Symposium (BIOELECTRICS 2013)}, year = {2013}, address = {Karlsruhe, Germany}, abstract = {

Pulsed Electric Field technologies have captured the attention of researchers on food pasteurization because of their non-thermal inactivation mechanism, which results in fresh-like products. Nevertheless, high voltage pulsing required by these technologies implies complex and costly generators. Here, as an alternative, it is proposed a method, partially inherited from research on cell electroporation for gene transfection, in which the liquid to be treated flows at high speed through a miniature chamber where the electric field is permanently applied. In particular, it is proposed that the constantly applied electric field consists of an AC signal (\> 100 kHz) so that electrochemical by-products are minimized. The method, while being compatible with batch processing, will allow use of lower voltages and will avoid the pulsation requirement.\ 

}, author = {J. Gonz{\'a}lez-Sosa and A. Ruiz-Vargas and G. Arias and Q. Castellv{\'\i} and Antoni Ivorra} }